Clinical Research at DZNE
The path to new therapies
Clinical research connects laboratories and the bedside: Newly developed substances and therapies are tested on patients, innovative treatment strategies are developed and diagnostic procedures and biomarkers are established. At the DZNE, Clinical Research focuses on a broad spectrum of neurodegenerative diseases - from dementias such as Alzheimer's to movement disorders such as Parkinson's and ALS.
To this end, scientists at the DZNE cooperate very closely with university hospitals throughout Germany; they also participate in international projects and consortia, thereby bringing together expertise from many different areas.
Improving diagnostic procedures plays an important role in clinical research: Because the brain in neurodegenerative diseases has often already changed many years or even decades before the first symptoms appear, early diagnosis is crucial for successful treatment. Our researchers are therefore looking for ways to detect the hidden beginnings of such diseases. Observational studies, on the other hand, are used to investigate the course of diseases and the development of clinical symptoms. Moreover, in treatment studies, the scientists are investigating new drugs and other therapeutic modalities.
Clinical research is based at the DZNE sites in Berlin, Bonn/Cologne, Dresden, Göttingen, Magdeburg, Munich, Rostock/Greifswald, Tübingen and Ulm.
Clinical Research Platform - CRP
The multi-site studies of the DZNE are supported and coordinated by the
Clinical Research Platform ...
Databases of Clinical Research
Here you'll find the Databases of DZNE's Clinical Research.
Further information regarding the access requirements can be found here.
Support: In case of questions or issues, please contact the data management of the clinical research platform: data-management-kf(at)dzne.de.
Requirements: The request form for database access, the declaration of commitment and the regulations for use of Clinical Research databases, data and biomaterial samples of the DZNE can be downloaded here:
- Request for access to the databases of the clinical research (German only)
- Declaration of commitment by users of the clinical databases (German only)
- Regulations for use of Clinical Research databases, data and biomaterials of the DZNE
The request form can be sent either by mail or e-mail, the declaration of commitment by mail only to the rights management of the clinical research:
Deutsches Zentrum für Neurodegenerativer Erkrankungen e.V.
Klinische Forschungsplattform - Rechtemanagement
Venusberg-Campus 1/99
D-53127 Bonn
zentrales-rechtemanagement-DB(at)dzne.de
Important note: In case PDF forms are not displayed properly using Firefox, e.g. without editable form fields, follow these instructions and choose "Open with Adobe Acrobat Reader": Disable the built in pdf-viewer and use another viewer
Clinical Data Search Tool - CDST
The Clinical Data Search Tool - CDST offers the opportunity to retrieve information on available data/materials from clinical research studies.
The CDST provides purely qualitative information (no number of available datasets) such as
- Forms (= examinations such as tests, scales, imaging, biomaterial, etc.) and
- Parameters (= Variables/Items),
for which results are available in the clinical research databases for a particular study.
For each study
- individual forms completely (> Formular drucken) as well as
- parameters from several forms (> ausgewählte Items: … > Auswahl drucken)
can be saved as a PDF file and, if necessary, attached to the Request for Data and Biomaterial.
Please note that this does not replace the request, it can serve only as a supplement.
Request for Data and Biomaterial / Biobank Report
The data/biomaterial request form and the regulations for use of Clinical Research databases, data and biomaterial can be downloaded here:
- Data/Biomaterial Request Form
- Regulations for use of Clinical Research databases, data and biomaterials of the DZNE
Please, send the request form to klinische-studien(at)dzne.de.
- Report of DZNE's Clinical Research Biobank (German only)
Important note: In case PDF forms are not displayed properly using Firefox, e.g. without editable form fields, follow these instructions and choose "Open with Adobe Acrobat Reader": Disable the built in pdf-viewer and use another viewer
Request consultation service
To ensure that your request is processed smoothly and that your needs and our requirements for the targeted handling of your request are met in the best possible way, our consulting team is at your disposal. We will help you prepare your application in order to
- clarify any potential questions or uncertainties in advance,
- ensure that your requirements and objectives are fully understood,
- support you in selecting the appropriate data and resources,
- facilitate and accelerate the process of your request.
We are convinced that a prior consultation will help to ensure an efficient and successful collaboration that will benefit both you and our team.
Please arrange a consultation at Data.ManagementKF@dzne.de.
Clinical Data Search Tool - CDST
Please also use the Clinical Data Search Tool - CDST to specify your request or to clarify in advance which parameters/biomaterial samples/MRT sequences/QA information/analysis results are available for the individual studies.
Central Contact Management / Content Responsibility
Central Contact Management
The central contact management is the point of contact for study participants (probands).
zentrale-kontaktstelle-kf(at)dzne.de
Content responsibility
The Clinical Research Platform is responsible for the contents of DZNE's Clinical Research website.
DECLARE - DZNE Clinical Research E-Learning Platform
Here you'll find DECLARE, the DZNE Clinical Research E-Learning Platform. The Terms of Use can be downloaded here:
Regarding access to DECLARE, please contact the Clinical Research Platform of the DZNE.
SARA Training Tool
The SARA training tool provides comprehensive and standardized training material to reduce variability in applying the SARA (Scale for Assessment and Rating of Ataxia). The SARA scores shown were recorded according to a standardized protocol and rated by three clinical experts in consensus.
Four hundred thirty-eight videos of 67 patients are included in the SARA training tool:
- The tutorial section demonstrates a complete SARA examination on a healthy control.
- In the training section, users can access a video library covering the complete SARA range and compare their ratings to consensus ratings.
- The tool also includes a section that allows optional certification.
- More information about SARA:
Members of the Ataxia Global Initiative can apply for free access to the SARA Training Tool using this request form. Be sure to include a copy (PDF) of your membership certificate with your application.
To apply for free membership of the Ataxia Global Initiative, please contact the Ataxia Global Initiative directly.
For fee-based use of the SARA Training Tool in the context of commercial clinical trials, please contact our Technology Transfer Office.
For further questions on the use of the SARA Training Tool (e.g., for scientific use independent of the membership in the Ataxia Global Initiative), please contact the Clinical Research Platform of the DZNE.
German Network of Memory Outpatient Clinics (DNG)
The German Network of Memory Outpatient Clinics (DNG - Deutsches Netzwerk Gedächtnisambulanzen) offers its members training and exercise material (in German only) for standardized diagnostics. The content provided has been created and reviewed by the DNG working groups. Further information on learning content can be obtained from the e working group leaders.
Members of the DNG can apply for free access to the DECLARE learning platform using this form. Please be sure to enclose a copy (PDF) of your membership certificate with your application.
Please apply for the DNG membership certificate by e-mail to Jennifer Michels (Universitätsklinikum Aachen). Please send the application form and membership certificate to the Clinical Research Platform of the DZNE.
