Clinical research at the Rostock/Greifswald site
Clinical research at the DZNE Rostock/Greifswald focuses on the transfer of new diagnostic and intervention concepts from methodological development via experimental settings to routine care:
- Improvement of diagnostics of dementia diseases by means of imaging, biomarker research, and brain tissue investigations
- Development and improvement of new prevention and therapy concepts
- Development and application of participatory research methods to involve patients and their relatives in the planning, execution and implementation of research projects and their results
- Development of systems to improve daily living skills in order to enhance the quality of life of people with dementia and their relatives
- Characterisation and treatment of non-motor disorders in movement disorders, such as Parkinson's disease, and other predominantly motor neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS)
- Investigations of cognitive disorders by combining learning and memory tests with functional and innovative morphological imaging techniques
- Cross-correlation of cognitive reserve and motor disease progression and vice versa
- Investigation of cognition and behavior of ALS patients
- Longitudinal studies of prodromal stages of neurodegenerative diseases and predictive ability of conversion
- Combined longitudinal studies (clinical, (molecular) imaging, biomarkers, post mortem analyses) to evaluate dynamic changes of structural and functional networks
- Development of novel therapeutic concepts for neurodegenerative diseases (e.g. iPSZ models, THS, ferroptosis).
- Development and testing of machine learning and artificial intelligence (AI) methods to support diagnostics and care.
Head of clinical research Rostock/Greifswald
Clinical Research Groups / Principle Investigators
- Dr. Martin Dyrba - Project: Neural networks - system architecture for multimodal explanations
- Prof. Dr. Agnes Flöel - Dementia prevention: mechanisms and clinical implementation
- Prof. Dr. Hans Grabe - Biomarkers of dementia in the general population
- Prof. Dr. Dr. Andreas Hermann - Motor neuron disease
- Dr. Wiebke Hermann - Prodromal stages of neurodegenerative diseases and Sleep Medicine
- PD Dr. med. Christoph Kamm - Motoneuron diseases, frontotemporal dementia
- Dr. Matthias Löhle - Clinical Research in Movement disorders
- Prof. Dr. Johannes Prudlo - Movement disorders
- Prof. Dr. Alexander Storch - Non-motor symptoms in Parkinson's disease
- Prof. Dr. Stefan Teipel - Clinical Dementia Research
Local clinical research facilities
- Research Outpatient Clinic for Neurodegenerative Diseases with a focus on
- Memory impairment
- Movement disorders
- Motoneuron diseases
- Frontotemporal lobar degenerations (FTD, PSP, CBS)
- Prodromal neurodegenerative diseases / sleep disorders
- Monogenetic neurodegenerative diseases
- Brainbank
Local cooperation partners
- Universitätsmedizin Rostock
- Clinic and Polyclinic for Neurology
- Clinic and Polyclinic for Nuclear Medicine
- Institute of Pathology
- Clinic und Polyiclinic for Psychosomatics and Psychotherapeutic Medicine
- Institute of Forensic Medicine
- Institute for Diagnostic and Interventional Radiology, Pediatric and Neuroradiology
- Institute for Clinical Chemistry and Laboratory Medicine
- Institute for Biostatistics and Informatics in Medicine and Aging Research
- Oscar Langendorff Institute of Physiology
- Department of Psychiatry, Neurology, Psychosomatics and Psychotherapy in Childhood and Adolescence
- Universität Rostock
- Universitätsmedizin Greifswald
- Deutsche Alzheimer Gesellschaft, Landesverband Mecklenburg-Vorpommern e.V., Selbsthilfe Demenz
- Deutsche Gesellschaft für Muskelkranke, Landesverband Mecklenburg-Vorpommern e.V.